09-811 Special Topics in Organic Chemistry and Chemical Biology: Environ Exposure&Risk
12 units, Carnegie Mellon University
Our world is full of synthetic and naturally occurring toxic chemicals, presenting an imminent but difficulttoquantify threat for human and ecosystem health. In this papersbased course we will ask the question, How do we decide whats safe in the context of exposure and risk assessment for toxic environmental pollutants. We will complete a series of case studies featuring current and seminal literature, inclass activities, and projectbased assignments. Each case study will focus on a distinct contaminant exposure scenario and will be linked back to the common theme of using chemistry to understand how external exposure leads to internal dose and subsequent health impacts for diverse environmental pollutants. We will discuss how knowledge generated in the laboratory can be translated and used to inform regulatory decisions. The first half of the course will focus on contaminant bioavailability, exposure, and toxic effects in aquatic organisms. In the second half of the course, we will discuss human exposure to toxic pollutants and strategies to assess risks in the human population, including the human exposome concept, omicsbased research, and strategies for discovering novel harmful contaminants.
Prerequisites: (09-106 or 09-107) and (09-217 or 03-232 or 09-219 or 03-231)
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