09-717 Organotransition Metal Chemistry
12 units, Carnegie Mellon University
Definitions, main structural types, and polyhedrons of organometallic complexes will be presented. Molecular orbitals of ligands, bond formation, MOLCAO molecular orbitalslinear combination of atomic orbitals approach will be reviewed. Simple metal carbonyls, complexes with similar to CO ligands CN, N2, NO will be analyzed in terms of 18e rule. Alkene, alkyne, allyl, cyclopentadienyl, and arene complexes will be introduced. Differences between Fischer electrophilic and Schrock nucleophilic carbenes will be discussed. Trans influence and trans effect, substitution reaction mechanisms, mechanisms of oxidative addition, reductive elimination, and electrophilic substitution will be analyzed. Importance of CH bond activation by organometallic compounds will be highlighted. Insertion, deinsertion, or betaelimination of CO, alkenes, and alkynes will be presented. Nucleophilic addition to coordinated alkenes, allylic and other ligands will be demonstrated. Role of organometallics in homogeneous catalytic reactions WackerSmidt and Monsanto synthesis, hydroformylation, polymerization, metathesis will be emphasized. Modern aspects of bioorganometallic chemistry will be introduced. Properties of hemoglobin, vitamin B12, organometallic lyases will be considered. Enzymatic redox transformations of organometallics, biochemistry of ferrocene, organometallics as anticancer drugs and probes in receptor analysis will be presented. 3 hrs. lec.
Prerequisites: none listed
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