03-428 Genome Editing

6 units, Carnegie Mellon University

How can we create genetically engineered cells, animals, plants, and even humans This course will focus on the technologies that enable genome modification, with an emphasis on the recently developed CRISPRCas9 system. Specific topics will include an introduction to CRISPR technology and its history DNA double strand break repair Off target effects Gene regulator CRISPRs Alternate technologies Ethics of modifying our genomes Applications cell screening Applications organism engineering Applications antiHIV and immunotherapy Overview of Gene therapy.

Prerequisites: 03-121 or 03-709 or 03-151

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